Tsutomu Nakahara Selected Research

N-Methylaspartate (NMDA)

4/2021	Metformin Protects against NMDA-Induced Retinal Injury through the MEK/ERK Signaling Pathway in Rats.
1/2019	Involvement of matrix metalloproteinases in capillary degeneration following NMDA-induced neurotoxicity in the neonatal rat retina.
1/2018	Iron-chelating agents attenuate NMDA-Induced neuronal injury via reduction of oxidative stress in the rat retina.
1/2018	Retinal neuronal cell loss prevents abnormal retinal vascular growth in a rat model of retinopathy of prematurity.
1/2018	[Selective neuronal cell death in retinal degenerative diseases].
10/2017	Opioid receptor activation is involved in neuroprotection induced by TRPV1 channel activation against excitotoxicity in the rat retina.
9/2017	Activation inhibitors of nuclear factor kappa B protect neurons against the NMDA-induced damage in the rat retina.
12/2016	Protective effects of PF-4708671 against N-methyl-d-aspartic acid-induced retinal damage in rats.
11/2016	Apelin-36 is protective against N-methyl-D-aspartic-acid-induced retinal ganglion cell death in the mice.
8/2015	High-mobility group Box-1 is involved in NMDA-induced retinal injury the in rat retina.

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Tsutomu Nakahara Research Topics

Disease

26	Ganglion Cysts (Ganglion) 01/2022 - 08/2009
12	Retinal Diseases 01/2018 - 05/2009
11	Glaucoma 01/2020 - 05/2009
11	Ischemia 04/2018 - 07/2004
8	Cataract (Cataracts) 01/2019 - 01/2008
7	Diabetic Retinopathy (Retinopathy, Diabetic) 03/2021 - 08/2009
6	Neoplasms (Cancer) 01/2020 - 02/2006
6	Hypoxia (Hypoxemia) 01/2020 - 01/2011
6	Retinal Degeneration 01/2019 - 11/2010
4	Retinopathy of Prematurity (Retrolental Fibroplasia) 08/2021 - 02/2016
4	Diabetes Mellitus 03/2021 - 08/2008
4	Hyperglycemia 01/2019 - 06/2009
4	Inflammation (Inflammations) 12/2018 - 08/2009
4	Reperfusion Injury 08/2015 - 05/2009
4	Fetal Growth Retardation (Intrauterine Growth Retardation) 08/2014 - 01/2010
3	Pathologic Neovascularization 01/2020 - 01/2014
3	Wounds and Injuries (Trauma) 09/2019 - 08/2009
3	Hyperalgesia 01/2014 - 12/2012
2	Vascular Diseases (Vascular Disease) 08/2021 - 05/2015
2	Premature Birth (Birth, Premature) 08/2021 - 02/2013
2	Retinitis Pigmentosa (Pigmentary Retinopathy) 01/2018 - 01/2011
2	Hyperoxia 12/2016 - 10/2015
2	Pre-Eclampsia (Preeclampsia) 03/2014 - 01/2010
2	Neuralgia (Stump Neuralgia) 01/2013 - 12/2012
2	Cystitis 01/2011 - 02/2004
2	Hypertension (High Blood Pressure) 01/2010 - 06/2007
2	Carcinoma (Carcinomatosis) 10/2006 - 02/2006
2	Cardiovascular Diseases (Cardiovascular Disease) 02/2004 - 04/2003
1	Cardiomegaly (Heart Hypertrophy) 01/2022
1	Colitis-Associated Neoplasms 01/2020
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020
1	Choroidal Neovascularization 01/2019
1	Uveitis 12/2018
1	Blindness (Hysterical Blindness) 01/2018

Drug/Important Bio-Agent (IBA)

36	Retinaldehyde (Retinal)IBA 08/2021 - 07/2004
27	N-Methylaspartate (NMDA)IBA 04/2021 - 05/2009
14	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2020 - 02/2006
10	Glutamic Acid (Glutamate)FDA Link 01/2018 - 08/2009
8	Streptozocin (Streptozotocin)FDA Link 01/2019 - 01/2008
6	Vasodilator Agents (Vasodilators)IBA 08/2021 - 06/2007
6	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 04/2018 - 10/2006
5	Pharmaceutical PreparationsIBA 01/2019 - 04/2008
5	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2017 - 05/2009
4	Glucose (Dextrose)FDA LinkGeneric 01/2019 - 01/2008
4	Drinking WaterIBA 01/2019 - 01/2008
4	Acetylcholine (Acetylcholine Chloride)FDA Link 02/2015 - 06/2009
4	N- (2- chloro- 4- ((6,7- dimethoxy- 4- quinazolinyl)oxy)phenyl)- N'- propylureaIBA 08/2014 - 01/2010
3	Proteins (Proteins, Gene)FDA Link 01/2022 - 04/2003
3	Calcitonin (Calcitonin, Eel)FDA LinkGeneric 01/2014 - 12/2012
3	Oxaliplatin (Eloxatin)FDA LinkGeneric 01/2014 - 12/2012
3	elcatoninIBA 01/2014 - 12/2012
3	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2011 - 02/2004
2	ParvalbuminsIBA 04/2021 - 10/2013
2	Probucol (Lorelco)FDA Link 01/2019 - 12/2017
2	SugarsIBA 01/2019 - 04/2008
2	Crystallins (Crystallin)IBA 01/2019 - 01/2018
2	Neuroprotective AgentsIBA 12/2018 - 05/2009
2	Purinergic P2X7 ReceptorsIBA 12/2018 - 06/2015
2	Opioid Receptors (Opioid Receptor)IBA 01/2018 - 10/2017
2	ResveratrolIBA 01/2018 - 09/2011
2	Nitric Oxide Synthase (NO Synthase)IBA 01/2018 - 03/2006
2	Capsaicin (Zostrix)FDA Link 10/2017 - 06/2014
2	Oxygen (Dioxygen)IBA 12/2016 - 01/2014
2	Amlodipine (Norvasc)FDA LinkGeneric 10/2015 - 05/2009
2	Everolimus FDA Link 01/2015 - 01/2014
2	Sirolimus (Rapamycin)FDA Link 01/2015 - 01/2014
2	Tyrosine Kinase InhibitorsIBA 08/2014 - 08/2013
2	Messenger RNA (mRNA)IBA 03/2014 - 04/2003
2	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 08/2013 - 02/2013
2	Paclitaxel (Taxol)FDA LinkGeneric 01/2013 - 12/2012
2	GP 1447IBA 01/2012 - 01/2008
2	Aldehyde Reductase (Aldose Reductase)IBA 01/2012 - 01/2008
2	polyolIBA 01/2012 - 01/2010
2	BradykininIBA 09/2011 - 01/2011
2	Donepezil (Aricept)FDA LinkGeneric 01/2010 - 01/2010
2	Axitinib (AG 013736)IBA 10/2006 - 02/2006
1	malic acid (malate)IBA 01/2022
1	Aspartic Acid (Aspartate)FDA Link 01/2022
1	Serine (L-Serine)FDA Link 01/2022
1	Ouabain (G Strophanthin)IBA 01/2022
1	CitrullineIBA 03/2021
1	CationsIBA 01/2020
1	SodiumIBA 01/2020
1	Ion Channels (Ion Channel)IBA 01/2020
1	Dextrans (Dextran)FDA Link 01/2020
1	MicroRNAs (MicroRNA)IBA 01/2020
1	Calbindin 2IBA 04/2019
1	AntioxidantsIBA 01/2019
1	Hypolipidemic Agents (Antihyperlipidemics)IBA 01/2019
1	LipidsIBA 01/2019
1	GTP-Binding Proteins (G-Protein)IBA 01/2019
1	coomassie Brilliant BlueIBA 12/2018
1	EndotoxinsIBA 12/2018
1	Pyruvaldehyde (Methylglyoxal)IBA 01/2018
1	Amino Acid Transport System X-AG (Glutamate Transporter)IBA 01/2018
1	Iron Chelating AgentsIBA 01/2018

Therapy/Procedure

10	Intravitreal Injections 01/2022 - 01/2013
4	Therapeutics 01/2020 - 02/2006
2	Lenses 01/2012 - 01/2008
2	Aftercare (After-Treatment) 10/2006 - 02/2006